Val Landi has an interesting post on his blog about whether the current US mainstream publishers can or cannot bring themselves to publish a book with a terrorist theme.
It's a matter on which he has pondered before, and it is, of course, all related to his own ms in search of a publisher (A Woman from Cairo). Nevertheless, this post should certainly give pause for thought to anyone who, filled with enthusiasm, is about to devote the next year or two to writing a novel.
Who knows what will happen in that time? And who can say how it will affect the way in which editors will view your masterpiece? And might there not, in all seriousness, be less risky and more productive ways to spend your time?
Proceed if you must. But it is, as always, a pretty desperate gamble.